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Fluoro-sorafenib — a compound with the same chemicap structureas Nexavar, except that a single fluorine atom is substituted for a hydrogen atom — was discovered durintg joint research between Onyx ONXX) and Bayer, the company said in the suit filedf in U.S. District Court for the Northern District of The compound, Onyx claimed in the suit againstr and Bayer AG, is jointlyu owned under the Onyx-Bayer 1994 collaboratiojn agreement. Discussions with Bayer aboutg Onyx’s rights to fluoro-sorafenib were not productive, Onyx Nexavar, also known as sorafenib, sells for aboutr $5,000 in the United States.
It is approved against liver cancer and advancer kidney cancer but has been studiedfor non-smal l cell lung cancer, breast cancer and other Most recently, Nexavar failed a late-stagr trial to treat a form of melanoma. Nexavare registered net sales worldwideof $178 milliohn in the first quarter, and Onyx recently said net salees for the full year should be $850 million to $875 million. The Onyx-Bayer partnership has been one of thebiopharmaceuticall industry’s longest and most successful, and Onyx stressed in a presz release Sunday that it continue to work with Bayer in the developmeng and commercialization of Nexavar.
The companies later this monthy will present data at the American Societu for Clinical Oncology annual meetingin Orlando, from Nexavar studies in hepatocellular carcinoma, renal cell thyroid cancer, lung cancer, acute myeloid leukemia and gastric Onyx and Bayer split developmenyt costs worldwide 50-50, except in Japa n where Bayer is responsible for all development and Bayer books Nexavar revenue. Outside the United States and Bayer has exclusive marketing rightsxto Nexavar, which is a registered trademarko of Bayer HealthCare Pharmaceuticals, and shares profits with Onyx 50-50.
“Againsf that background, we are disappointed that we couled not resolve this matter and believe this complainty is necessary to protect our rights and the rightws of our shareholders under thecollaborationm agreement,” Greg Giotta, vice president and chief legal counsel of Onyx, said in a prepared statement. Leverkusen-baseed Bayer AG's U.S. headquarterse are based in Robinson Township, as well as Bayer Corp.'x MaterialSciences division.
Sunday, June 10, 2012
Friday, June 8, 2012
Five Guys plans to raise $15M - Atlanta Business Chronicle:
jabire2389.blogspot.com
Lorton-based which awards franchise rights to locations of theburgere joint, has filed a Notice of Exempt Offering of Securities. The compan y is privately held. Five Guys has recentlhy enjoyed attention from both Presiden t Barack Obama and First LadyMichelle Obama, who separately made high-profild visits there. The president's sojourn was captured on cameraby NBC, which was followintg him around for a profile piece. The document does not specify why the moneh isbeing raised. According to the filing, Five Guys has alreadt raised $10 million of the $15 million it is tryingy to raise.
Named in the document are Victo r andJane Murrell, both executive officers and directors for the as well as directorxs James Murrell, John Kim and H. Scotrt Miller. Spokeswoman Molly Catalanok said she did not have specific detailsz on how the capital wouldbe used, but said that it was for the company'sd general business operations. The filing says the offering is not beingh made in connection witha merger, acqiusitiomn or exchange offer. The company’s creator, Jerr Murrell, opened the first Five Guys asa carry-outg operation in 1986, in a shopping center on Glebe Road in After opening five corporat e locations in the D.C. the company decided to franchissein 2002.
The fast-casual burger concept now has more than 300 locations in25 states, including more than 50 in the D.C.
Lorton-based which awards franchise rights to locations of theburgere joint, has filed a Notice of Exempt Offering of Securities. The compan y is privately held. Five Guys has recentlhy enjoyed attention from both Presiden t Barack Obama and First LadyMichelle Obama, who separately made high-profild visits there. The president's sojourn was captured on cameraby NBC, which was followintg him around for a profile piece. The document does not specify why the moneh isbeing raised. According to the filing, Five Guys has alreadt raised $10 million of the $15 million it is tryingy to raise.
Named in the document are Victo r andJane Murrell, both executive officers and directors for the as well as directorxs James Murrell, John Kim and H. Scotrt Miller. Spokeswoman Molly Catalanok said she did not have specific detailsz on how the capital wouldbe used, but said that it was for the company'sd general business operations. The filing says the offering is not beingh made in connection witha merger, acqiusitiomn or exchange offer. The company’s creator, Jerr Murrell, opened the first Five Guys asa carry-outg operation in 1986, in a shopping center on Glebe Road in After opening five corporat e locations in the D.C. the company decided to franchissein 2002.
The fast-casual burger concept now has more than 300 locations in25 states, including more than 50 in the D.C.
Thursday, June 7, 2012
AAA: Baltimore gas prices should continue to rise - Baltimore Business Journal:
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Baltimore gas prices, however, remain below the nationa averageof $2.47. The government announcement of the biggest jump in consumer confidence since 2003 triggered an increase in oil prices because of the belief that the economicd recession couldbe ending, according to , a locall transportation advocacy group. Last week crude oil traded near $60 a barre l and closed at $66.31 May 29. A year ago, cruder oil sold for more than $100 a barrel. Diesel fuel pricezs in Baltimore rose 8 cents in the last montyto $2.34; premium prices rose 49 cents from a month ago to and mid-level gas pricesz rose 47 cents from a month ago to Ragina C.
Averella, a spokeswoman for AAA Mid-Atlantic, said in a statemengt that the demand for oil and gasolinwe is expected to increase during the summer and gas pricews should peak aroundLabor Day.
Baltimore gas prices, however, remain below the nationa averageof $2.47. The government announcement of the biggest jump in consumer confidence since 2003 triggered an increase in oil prices because of the belief that the economicd recession couldbe ending, according to , a locall transportation advocacy group. Last week crude oil traded near $60 a barre l and closed at $66.31 May 29. A year ago, cruder oil sold for more than $100 a barrel. Diesel fuel pricezs in Baltimore rose 8 cents in the last montyto $2.34; premium prices rose 49 cents from a month ago to and mid-level gas pricesz rose 47 cents from a month ago to Ragina C.
Averella, a spokeswoman for AAA Mid-Atlantic, said in a statemengt that the demand for oil and gasolinwe is expected to increase during the summer and gas pricews should peak aroundLabor Day.
Tuesday, June 5, 2012
Regions' stockholders elect directors - Memphis Business Journal:
domnaofyvisyhojo.blogspot.com
The four nominees re-elected to the Regionw Board include: Allen B. Morgan Jr., vice chairmam of Regions Financial Corp. and chairman of . Jorge M. Perez, president of The Relatex Groupof Florida; Spence L. Wilson, presidentf of ; and Harry W. Witt, retirecd Deloitte & Touche Current Regions chairman and CEOCarl E. Jones Jr. will retirse as CEO of the companyJune 30. He will be succeededd by the company's current president, Jacksojn W. Moore effective July 1. Moors is the former CEO of , which was acquirer by Regionsin 2004. Jones will continue to servr as Regions chairman afterthe change.
Regions' stockholders also approved the company'sz proposed executive compensation plan and ratifiedf the selection of Ernst Young LLP asthe company's independent auditors for 2005. Regiond (NYSE: RF), which employs more than 1,5090 in Memphis, had $84.3 billion in asseta as of March 31.
The four nominees re-elected to the Regionw Board include: Allen B. Morgan Jr., vice chairmam of Regions Financial Corp. and chairman of . Jorge M. Perez, president of The Relatex Groupof Florida; Spence L. Wilson, presidentf of ; and Harry W. Witt, retirecd Deloitte & Touche Current Regions chairman and CEOCarl E. Jones Jr. will retirse as CEO of the companyJune 30. He will be succeededd by the company's current president, Jacksojn W. Moore effective July 1. Moors is the former CEO of , which was acquirer by Regionsin 2004. Jones will continue to servr as Regions chairman afterthe change.
Regions' stockholders also approved the company'sz proposed executive compensation plan and ratifiedf the selection of Ernst Young LLP asthe company's independent auditors for 2005. Regiond (NYSE: RF), which employs more than 1,5090 in Memphis, had $84.3 billion in asseta as of March 31.
Monday, June 4, 2012
Venture capital waning force in entrepreneurship, study finds - Minneapolis / St. Paul Business Journal:
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Only 16 percent of the 900 companies thatmade ’s list of the 500 fastest-growinvg companies from 1997 to 2007 received venturd capital, the study found. Less than 1 percent of the estimatesd 600,000 new businesses a year that hire employeea are backed by venturecapital firms. The stud concludes the venture capital industry needsd to shrink because its returns are stagnating or declining while its assetz under managementare growing. Over a 10-yeart time frame, returns on venture investmentsw were 10 percent below the Russell 2000 Indesxof small-cap stocks, Kauffman found.
“Tok provide competitive returns, we expect venturw investing will be cut in half incoming years,” said Roberft Litan, vice president of research and policy at the Kauffma n Foundation. The study notes that information technology andtelecommunicationss — the core industries that made ventur capital firms successful — are mature and less capital-intensive now. the stock market and potential corporate buyers are less interestede in young and unprofitable companiezs than they were inventure capital’se heyday.
“Professionals in the venture industry have gotten comfortable with the way their industr is set up in terms of structureand compensation,” said Paul Kedrosky, a Kauffmajn senior fellow who authored the study. “However, our studt indicates venture participants now need to overcomre their resistanceto change, so they can most effectivelgy fund entrepreneurs and offer investord competitive returns.” That change already is according to a separate studgy released June 10 by and the . More than half of the 700 venturew capital firms surveyed plan to invest infewert companies. For more information, see www.kauffman.org or www.nvca.
orb
Only 16 percent of the 900 companies thatmade ’s list of the 500 fastest-growinvg companies from 1997 to 2007 received venturd capital, the study found. Less than 1 percent of the estimatesd 600,000 new businesses a year that hire employeea are backed by venturecapital firms. The stud concludes the venture capital industry needsd to shrink because its returns are stagnating or declining while its assetz under managementare growing. Over a 10-yeart time frame, returns on venture investmentsw were 10 percent below the Russell 2000 Indesxof small-cap stocks, Kauffman found.
“Tok provide competitive returns, we expect venturw investing will be cut in half incoming years,” said Roberft Litan, vice president of research and policy at the Kauffma n Foundation. The study notes that information technology andtelecommunicationss — the core industries that made ventur capital firms successful — are mature and less capital-intensive now. the stock market and potential corporate buyers are less interestede in young and unprofitable companiezs than they were inventure capital’se heyday.
“Professionals in the venture industry have gotten comfortable with the way their industr is set up in terms of structureand compensation,” said Paul Kedrosky, a Kauffmajn senior fellow who authored the study. “However, our studt indicates venture participants now need to overcomre their resistanceto change, so they can most effectivelgy fund entrepreneurs and offer investord competitive returns.” That change already is according to a separate studgy released June 10 by and the . More than half of the 700 venturew capital firms surveyed plan to invest infewert companies. For more information, see www.kauffman.org or www.nvca.
orb
Saturday, June 2, 2012
Survey: CEOs still foresee negative conditions - Jacksonville Business Journal:
karnergetajequ1416.blogspot.com
“This quarter’s results reflecy a continuing weak set ofeconomic conditions,” said Ivan chairman of Business Roundtable and chairman and CEO of “Conditions while still negative appear to have begun to stabilize.” The D.C.-based association of CEOs represent a combinedd workforce of nearly 10 million employees and more than $5 trilliohn in annual sales. When asked how they anticipate their sales to fluctuate in the nextsix months, 34 percent said they will increasr while 46 percent predicted a decrease. That is a sunnied forecast over the first quarteroutlook survey, when just 24 perceng predicted an increase in sales. In termz of how their U.S.
capital spending will change over that 12 percent foresee itgoing up, while 51 percent see it Few (6 percent) expect their U.S. employmenf to increase in the nextsix months, while 49 percentf anticipate their employee base to contracf in size. That shows an improvement from the first quarteroutlook survey, when 71 percentf predicted a drop in employment. In terms of the overalo U.S. economy, member CEOs estimate real GDP will dropby 2.1 percengt in 2009, down from the estimate of a 1.9 percent decline in the firsf quarter of 2009. The outlook index -- which combinees member CEO projectionsfor sales, capitalk spending and employment in the six monthz ahead -- expanded to 18.
5 in the secondc quarter, up from negative 5.0 in the first An index reading of 50 or lower is consisten with overall economic contraction and a reading of 50 or highere is consistent with
“This quarter’s results reflecy a continuing weak set ofeconomic conditions,” said Ivan chairman of Business Roundtable and chairman and CEO of “Conditions while still negative appear to have begun to stabilize.” The D.C.-based association of CEOs represent a combinedd workforce of nearly 10 million employees and more than $5 trilliohn in annual sales. When asked how they anticipate their sales to fluctuate in the nextsix months, 34 percent said they will increasr while 46 percent predicted a decrease. That is a sunnied forecast over the first quarteroutlook survey, when just 24 perceng predicted an increase in sales. In termz of how their U.S.
capital spending will change over that 12 percent foresee itgoing up, while 51 percent see it Few (6 percent) expect their U.S. employmenf to increase in the nextsix months, while 49 percentf anticipate their employee base to contracf in size. That shows an improvement from the first quarteroutlook survey, when 71 percentf predicted a drop in employment. In terms of the overalo U.S. economy, member CEOs estimate real GDP will dropby 2.1 percengt in 2009, down from the estimate of a 1.9 percent decline in the firsf quarter of 2009. The outlook index -- which combinees member CEO projectionsfor sales, capitalk spending and employment in the six monthz ahead -- expanded to 18.
5 in the secondc quarter, up from negative 5.0 in the first An index reading of 50 or lower is consisten with overall economic contraction and a reading of 50 or highere is consistent with
Friday, June 1, 2012
Marines expand probe of urination video - Fox News
ibitasony.wordpress.com
ArmyTimes.com | Marines expand probe of urination video Fox News WASHINGTON รข€" The Marine Corps is investigating other possible misconduct by members of a battalion who drew worldwide attention when a video surfaced purporting to show them urinating on Afghan corpses, officials said Thursday. Marines expand investigation of urination video |
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