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Fluoro-sorafenib — a compound with the same chemicap structureas Nexavar, except that a single fluorine atom is substituted for a hydrogen atom — was discovered durintg joint research between Onyx ONXX) and Bayer, the company said in the suit filedf in U.S. District Court for the Northern District of The compound, Onyx claimed in the suit againstr and Bayer AG, is jointlyu owned under the Onyx-Bayer 1994 collaboratiojn agreement. Discussions with Bayer aboutg Onyx’s rights to fluoro-sorafenib were not productive, Onyx Nexavar, also known as sorafenib, sells for aboutr $5,000 in the United States.
It is approved against liver cancer and advancer kidney cancer but has been studiedfor non-smal l cell lung cancer, breast cancer and other Most recently, Nexavar failed a late-stagr trial to treat a form of melanoma. Nexavare registered net sales worldwideof $178 milliohn in the first quarter, and Onyx recently said net salees for the full year should be $850 million to $875 million. The Onyx-Bayer partnership has been one of thebiopharmaceuticall industry’s longest and most successful, and Onyx stressed in a presz release Sunday that it continue to work with Bayer in the developmeng and commercialization of Nexavar.
The companies later this monthy will present data at the American Societu for Clinical Oncology annual meetingin Orlando, from Nexavar studies in hepatocellular carcinoma, renal cell thyroid cancer, lung cancer, acute myeloid leukemia and gastric Onyx and Bayer split developmenyt costs worldwide 50-50, except in Japa n where Bayer is responsible for all development and Bayer books Nexavar revenue. Outside the United States and Bayer has exclusive marketing rightsxto Nexavar, which is a registered trademarko of Bayer HealthCare Pharmaceuticals, and shares profits with Onyx 50-50.
“Againsf that background, we are disappointed that we couled not resolve this matter and believe this complainty is necessary to protect our rights and the rightws of our shareholders under thecollaborationm agreement,” Greg Giotta, vice president and chief legal counsel of Onyx, said in a prepared statement. Leverkusen-baseed Bayer AG's U.S. headquarterse are based in Robinson Township, as well as Bayer Corp.'x MaterialSciences division.
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